The series follows protagonists Jayce, Flora, Herc Stormsailor, Oon, and Gillian in their search for Jayce's father Audric while opposing the main antagonist Saw Boss and his followers, the Monster Minds. Audric was a botanist who performed experiments with biotechnology, one experiment creating Flora. In another experiment, Audric attempted to create a plant that could prevent starvation. But when he succeeded, a nearby star exploded into a supernova. The radiation from the supernova's explosion changed the plant and four others into the Monster Minds: a race of plant-like extraterrestrials who wished to conquer the universe. Audric created a root that could destroy the Monster Minds, but was forced to flee before he could complete the task, after which the Monster Minds made Audric's laboratory their headquarters. Audric kept half of the root himself and gave the other half to his servant, the Eternal Squire Oon, whom he sent to serve Jayce. Jayce and his friends are thereafter on a quest to find Audric and form the complete root.