In the Wild West town of Nice and Friendly Corners, everyone is an anthropomorphic and cute animal. They all get along and are friendly to each other. However, there are times when the townsfolk get into problems or don't get along with each other. The series follows Sheriff Callie, a female calico cat and the sheriff alongside her friends Deputy Peck, a male red woodpecker and keeper of the town jail and Toby, a male saguaro cactus. Together they all solve problems and teach the townsfolk to get along with each other while working hard to make the town the friendliest in the west.