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Episode Title: Monsters vs. Aliens.
Episode Description: Susan Murphy (Reese Witherspoon) of Modesto, California is going to be married to news weatherman Derek Dietl (Paul Rudd). But before the ceremony, she gets hit by a meteorite and its energy causes her to grow uncontrollably during the ceremony. As a side-effect, her hair turns white. She is tranquilized by the military and awakens in a top secret government facility that houses monsters without human knowledge. She meets the warden W.R. Monger, and fellow inmates: Dr. Cockroach P.H.D. (Hugh Laurie), a mad scientist who became half cockroach after an experiment; B.O.B. (Benzoate Ostylezene Bicarbonate) (Seth Rogen), a brainless, living mass of goo as a result of a food flavoring mutation; Insectosaurus, a mutated bug standing at 350 feet in height, and the Missing Link (Will Arnett), a prehistoric fish man who was thawed from deep ice. Susan herself has been renamed to Ginormica.
In deep space, an alien overlord named Gallaxhar (Rainn Wilson) is alerted to the presence of quantonium, a powerful energy source on Earth, and he sends a probe to retrieve it. The probe later lands on Earth where the President of the United States (Stephen Colbert) attempts to make first contact with it. However, the attempt fails and the probe goes on a destructive rampage, headed straight for San Francisco.
Monger arranges for the freedom of the monsters if they can stop the probe to which the president agrees. The robot detects the quantonium radiating through Susan's body and tries to take it from her. The monsters work together to save the people and defeat the probe.
Unbeknownst to the monsters, Gallaxhar sets course for Earth to obtain the quantonium in person while the now-free Susan returns home with her new friends and reunites with her family. However, the monsters alienate themselves from the humans due to their inexperience with social situations. Derek later breaks off his engagement with Susan, believing that he cannot marry someone who would overshadow him and his career. Heartbroken, the monsters reunite, but Susan realizes that her life is better as a monster and promises not to sell herself short to anyone again...